BeachGal Posted June 25, 2020 Share Posted June 25, 2020 One of China’s vaccines is moving on to Phase 3 clinical trials. This is the first inactivated virus vaccine to show efficacy. https://www.reuters.com/article/us-health-coronavirus-china-vaccine/china-to-run-human-coronavirus-vaccine-trial-in-uae-idUSKBN23U2H8 5 Quote Link to comment Share on other sites More sharing options...
JennyD Posted June 30, 2020 Author Share Posted June 30, 2020 Very upbeat and detailed article about treatments in the pipeline. Also, I may have linked to it before, but this blog on drug discoveries is one of the best out there, IMO. (I've linked to the most recent vaccine update.) 2 3 Quote Link to comment Share on other sites More sharing options...
Laura Corin Posted July 4, 2020 Share Posted July 4, 2020 https://covid.joinzoe.com/post/covid-estrogen-hrt Estrogen and C19 Quote Link to comment Share on other sites More sharing options...
Guest Posted July 4, 2020 Share Posted July 4, 2020 More hydroxychloraquine: https://amp.cnn.com/cnn/2020/07/02/health/hydroxychloroquine-coronavirus-detroit-study/index.html Syntax/grammar tangent: ...”helps coronavirus patients survive better...” Survive better? Such awkward phrasing. I continue to think everything surrounding this drug is fishy and someone, or some groups, are manipulating public beliefs about this drug for some self-interest, though I admit I am not certain who or what self-interest precisely. Quote Link to comment Share on other sites More sharing options...
Corraleno Posted July 4, 2020 Share Posted July 4, 2020 5 hours ago, Quill said: More hydroxychloraquine: https://amp.cnn.com/cnn/2020/07/02/health/hydroxychloroquine-coronavirus-detroit-study/index.html Syntax/grammar tangent: ...”helps coronavirus patients survive better...” Survive better? Such awkward phrasing. I continue to think everything surrounding this drug is fishy and someone, or some groups, are manipulating public beliefs about this drug for some self-interest, though I admit I am not certain who or what self-interest precisely. Thanks for linking that. There are quite a few issues with the Detroit study, including the fact that the HCQ group were younger and healthier to begin with than the nontreatment group, the exclusion of 267 patients who were still in the hospital, and the much higher use of beneficial steroids in the HCQ group: ""Finally, concomitant steroid use in patients receiving hydroxychloroquine was more than double the non-treated group. This is relevant considering the recent RECOVERY trial that showed a mortality benefit with dexamethasone." The steroid dexamethasone can reduce inflammation in seriously ill patients. Considering that the British study, which was a properly randomized clinical trial, found that steroids were very beneficial and HCQ was not, the Detroit data should be reanalyzed to determine how much of the benefit they saw in the HCQ group may have been attributable to the higher steroid use. The problem with these retrospective studies of nonrandomized treatment outcomes is that the same factors that make patients not good candidates for HCQ also make them higher risk for dying of Covid, so the patients that get HCQ are often less likely to die regardless of treatment. 1 1 Quote Link to comment Share on other sites More sharing options...
Laura Corin Posted July 7, 2020 Share Posted July 7, 2020 (edited) https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31483-5/fulltext BBC News - Coronavirus: Spanish study casts doubt on herd immunity feasibilityhttps://www.bbc.co.uk/news/world-europe-53315983 Edited July 7, 2020 by Laura Corin 1 Quote Link to comment Share on other sites More sharing options...
PrincessMommy Posted July 13, 2020 Share Posted July 13, 2020 Whoa, WTG Israel.... Israel Develops Antibody that Neutralizes CV and... Israel Invents the One-Minute CV Breath Test The first article does say it's still in the development phase, but it does sound hopeful. 5 1 Quote Link to comment Share on other sites More sharing options...
JennyD Posted July 30, 2020 Author Share Posted July 30, 2020 Super interesting summary and comparison of primate challenge studies of various vaccine candidates. 2 Quote Link to comment Share on other sites More sharing options...
mathnerd Posted August 26, 2020 Share Posted August 26, 2020 (edited) Moderna's vaccine produced antibodies in older people in trials and they are optimistic: https://www.reuters.com/article/us-health-coronavirus-cdc-moderna/moderna-covid-19-vaccine-appears-to-work-as-well-in-older-adults-in-early-study-idUSKBN25M1Y0 https://www.cnbc.com/2020/08/26/moderna-says-its-coronavirus-vaccine-shows-promising-results-in-small-trial-of-elderly-patients.html Edited August 26, 2020 by mathnerd 5 Quote Link to comment Share on other sites More sharing options...
mathnerd Posted September 9, 2020 Share Posted September 9, 2020 Effects of CV19 on brain cells: https://www.nytimes.com/2020/09/09/health/coronavirus-brain.html A new study offers the first clear evidence that in some people, the coronavirus invades brain cells, hijacking them to make copies of itself. The virus also seems to suck up all of the oxygen nearby, starving neighboring cells to death. 4 Quote Link to comment Share on other sites More sharing options...
Ausmumof3 Posted September 9, 2020 Share Posted September 9, 2020 20 minutes ago, square_25 said: In the realm of other depressing medical news, one of the vaccine trials was recently paused to investigate a possible adverse reaction: https://www.statnews.com/2020/09/08/astrazeneca-covid-19-vaccine-study-put-on-hold-due-to-suspected-adverse-reaction-in-participant-in-the-u-k/ Not sure if you saw the other thread but according to NYT it’s a case of transverse myelitis Quote Link to comment Share on other sites More sharing options...
Ausmumof3 Posted September 9, 2020 Share Posted September 9, 2020 3 minutes ago, square_25 said: Ah yeah, I did see it there. Sorry not to provide the full info! Just thought it worth putting this here, too. All good! I agree worth sharing again. Quote Link to comment Share on other sites More sharing options...
mathnerd Posted September 9, 2020 Share Posted September 9, 2020 49 minutes ago, square_25 said: *continues staying inside* *contemplates getting a giant plastic bubble to take the kids for walks in.* Ugh. Nothing I've learned about this virus is making me happy. I am right there with you! I just sent this to the person in my life who says that CV19 is less harmful than the flu, they survived the great polio outbreak just fine and that I should just go to their house and "wash my hands well" and everything will be OK. The irony is that they are the ones in the high risk category and I am the one who is trying to be protective of them. 1 Quote Link to comment Share on other sites More sharing options...
Bambam Posted September 9, 2020 Share Posted September 9, 2020 (edited) Re the stopped vaccine trial This is the second time the trial has been stopped: First time - woman diagnosed with MS ("the immune system attacks the protective sheath (myelin) that covers nerve fibers and causes communication problems between your brain and the rest of your body" ) but determined it was not related to vaccine. Second time - symptoms consistent with traverse myelitis. ( "This neurological disorder often damages the insulating material covering nerve cell fibers (myelin)") I find this concerning.https://www.statnews.com/2020/09/09/astrazeneca-covid19-vaccine-trial-hold-patient-report/ Edited September 9, 2020 by Bambam for clarity about 'second time' 2 Quote Link to comment Share on other sites More sharing options...
EmseB Posted September 9, 2020 Share Posted September 9, 2020 17 minutes ago, square_25 said: Second time of what? Second time of pausing the trial. 1 Quote Link to comment Share on other sites More sharing options...
ktgrok Posted September 9, 2020 Share Posted September 9, 2020 28 minutes ago, Bambam said: Re the stopped vaccine trial This is the second time: First time - woman diagnosed with MS ("the immune system attacks the protective sheath (myelin) that covers nerve fibers and causes communication problems between your brain and the rest of your body" ) but determined it was not related to vaccine. Second time - symptoms consistent with traverse myelitis. ( "This neurological disorder often damages the insulating material covering nerve cell fibers (myelin)") I find this concerning.https://www.statnews.com/2020/09/09/astrazeneca-covid19-vaccine-trial-hold-patient-report/ Definitely needs study, but when you have a big enough sample, you will have people develop weird stuff that may not be related at all. So a matter of unraveling if it is FROM the vaccine or a coincidence. 2 Quote Link to comment Share on other sites More sharing options...
Ausmumof3 Posted September 9, 2020 Share Posted September 9, 2020 1 hour ago, square_25 said: Yep. That's exactly the point of these larger trials -- to see if there are rare adverse effects, and of course, it's possible that it's entirely unrelated. It could absolutely just be a fluke. https://www.abc.net.au/radio/programs/coronacast/the-oxford-vaccines-troubles-why-its-not-doomed-yet/12646762 Coronacast had a segment on it today. Could be from the vaccine or could be random . Could be from the adenovirus part Of the vaccine or the coronavirus part. The adenovirus would be a better scenario because it will only impact vaccines using that method - the coronavirus part would be worst case because it would have Potential implications for all the vaccines. according to Wiki transverse myelitis is a four in a million people event. Quote Link to comment Share on other sites More sharing options...
Ausmumof3 Posted September 10, 2020 Share Posted September 10, 2020 Sorry to turn this into the astra Zeneca thread right now but they have said the rumours of transverse myelitis are incorrect they have no final diagnosis but it’s a neurological thing. Also the previous stop was due to someone being diagnosed with MS but is considered to have been pre existing and not linked to the vaccine. 3 Quote Link to comment Share on other sites More sharing options...
Ausmumof3 Posted September 10, 2020 Share Posted September 10, 2020 Also from further reading and if anyone knows more feel free to correct me but transverse myelitis with unknown cause can sometimes be a first sign of MS. If anyone knows more please chime in! Quote Link to comment Share on other sites More sharing options...
Ausmumof3 Posted September 10, 2020 Share Posted September 10, 2020 Just now, square_25 said: Hmmm, interesting. I found the original phrasing and it looks like “we don’t have a diagnosis but the symptoms are consistent with ...” Quote Link to comment Share on other sites More sharing options...
Bambam Posted September 12, 2020 Share Posted September 12, 2020 Trial resumeshttps://covid19vaccinetrial.co.uk/trial-resumes 3 Quote Link to comment Share on other sites More sharing options...
Ausmumof3 Posted September 13, 2020 Share Posted September 13, 2020 13 hours ago, Bambam said: Trial resumeshttps://covid19vaccinetrial.co.uk/trial-resumes I must admit I’d feel slightly happier if there was a little more info as to what specifically happened, and whether or not they think it’s vaccine linked. 1 Quote Link to comment Share on other sites More sharing options...
mathnerd Posted September 15, 2020 Share Posted September 15, 2020 University Of Pittsburgh Scientists Discover Biomolecule That May Neutralize Coronavirus University of Pittsburgh scientists have isolated a biomolecule that “completely and specifically” neutralizes the virus that causes coronavirus. University of Pittsburgh School of Medicine researchers isolated the smallest biological molecule to date that neutralizes the SARS-CoV-2 virus, according to a report published Monday in the journal Cell. The antibody component is 10 times smaller than a full-sized antibody and has been used to create a drug known as Ab8 for use as a therapeutic and preventative against SARS-CoV-2, the report says. https://pittsburgh.cbslocal.com/2020/09/14/pitt-scientists-discover-biomolecule-that-may-neutralize-coronavirus/ 2 Quote Link to comment Share on other sites More sharing options...
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