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BeachGal

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About BeachGal

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  1. Wearing masks until the vaccines are out is the best way to prevent overwhelming hospitals and closing down. It’s not 100% but it’s better than nothing. We could see vaccinations starting around December/January. Not one vaccine in phase 3 trials has shown ADE in humans or animals. England’s backup vaccine to their first choice, ChadOx, is showing to be very effective. They were not working on a universal cold vaccine but vaccines for MERS and SARS. The work stopped because the virus fizzled out and there was no need to continue making the vaccine. The research that went into them was used to make the Oxford vaccine, ChadOx.
  2. This is a preprint from the Karolinska Institute: https://www.biorxiv.org/content/10.1101/2020.06.29.174888v1.full.pdf Memory T cells hibernate in the bone marrow until they’re needed later if the virus should reappear. People are making antibodies but they disappear within a short-ish period of time. As long as we have memory T cells, recovered people and vaccines should be fine. However, some are having periods of recovery and flare-ups. From what I’ve read from immunologists, these are not true reinfections. Healing is a tough haul for them and they would be smart to maintain extremely healthy habits for weeks and months: no sugar/starchy food, no caffeine, no alcohol, careful with exercise, a lot of sleep and rest. One cup of coffee or a glass of wine and they feel like they did at their worst. The infection makes their blood like sludge and is also causing a lot of microclots. MDs are prescribing anti-coagulants for 1-2 months after infection. Probably takes awhile to get back to normal.
  3. Statistics can help to a degree but they aren’t going to give a clear picture because unfortunately, many crimes don’t get reported. My biggest concern and what has haunted me for decades are the suicides. On the Pine Ridge Reservation, suicides among preteen and adolescent Native Americans are about seven times higher than any other group of similarly-aged children in the US. The numbers are about six times higher on my former reservation. They tend to occur in clusters. It has been a serious problem for many years that warrants more attention and better programs than what are currently used. Wheels are finally turning but long-term effectiveness remains to be seen. Issues like suicide, drug and alcohol use, and poverty need to be addressed in ways that genuinely help and to do so requires people who will devote time and effort. There just aren’t many who will or can make that sort of commitment. Poverty among the Plains NA is not as clear cut as might appear, either, since they were historically rather anti-materialistic, and IMO, that still shapes life on Plains reservations today. Then there is the issue of purpose and meaning in life which I think is the crux of so many problems. Don’t get me wrong with what I’m saying here. I enjoyed living on the reservation. People are more genuine and accepting than anywhere else I’ve lived. It’s far less divisive than elsewhere and most people get along very well. However, in order to solve the problems, it’s important to figure out what is honestly happening. My concern regarding Oklahoma is whether it will bode well for vulnerable people. Who knows. Maybe it will.
  4. I grew up on a reservation and am part Sioux. My guess regarding Oklahoma is that crimes will be heard by tribal authorities and not the Fed. I do think that vulnerable native Americans, such as children and women, need far more protection than they had in the past and have currently. The neglect and abuse, including pedophilia and incest, was pretty alarming on my reservation. I do not believe the tribal leaders do enough to help because often they are protecting their own. I have known many people whose lives have been ruined either by way of suicide or other self destructive means. Life on many reservations is getting worse and will not change as long as tribal leaders protect those who are harming.
  5. Derek Lowe has a blog that you might like. Here’s an older entry from May where he discusses a paper from the LaJolla Institute for Immunology, UNC, UCSD, and Mt. Sinai that mentions among other things, that ADE is likely not going to be a problem. He’s written more in later posts, iirc. https://blogs.sciencemag.org/pipeline/archives/2020/05/15/good-news-on-the-human-immune-response-to-the-coronavirus The comments are worth reading, too. The reason I want to point this out is because there are some very dark, doom and gloom, life-will-never-be-the-same messages. Some people are barely hanging on and they really need to hear positive news, too.
  6. I’m lurking on some science forums where virologists, including Dengue experts, have been discussing this for awhile. They are not seeing antibody dependent enhancement (ADE) with the SARS2 virus. ADE was definitely a huge initial concern, though, because then it would be like Dengue. If you have sources that say it has ADE, I’d be interested in reading them. On a positive note, the Pfizer vaccine is looking good. They’ll be moving on to Phase 3 pretty soon. They are making doses at risk.
  7. Well, of course, “Happy” by Pharrell Williams! “Don’t Worry, Be Happy” by Bobby McFerrin ”Happy Talk” by Bloody Mary, South Pacific :D
  8. “Into Dust” Mazzy Star ”Sleepless Nights” Norah Jones “Mary Skeffington” Gerry Rafferty. He wrote it for his mother who was often beaten by her alcoholic husband. ”Sylvia’s Mother” Dr. Hook. Shel Silverstein wrote quite a few of their songs’ lyrics. This was one. ”Beggin’” Frankie Valli and the Four Seasons ”The Living Years” Mike and the Mechanics ”Cavatina” ”Tango to Evora” Loreena McKennitt “Slow Dancing in the Dark” Joji ”Where Did You Sleep Last Night/In the Pines” Leadbelly. I like Janel Drewis’s version. ”Hawaii ‘78” Israel Kamakawiwo’ole Some of the songs from Les Mis: Fantine’s Death, The ABC Cafe, On My Own, Bring Him Home, Empty Chairs at Empty Tables Some of Nick Drake’s songs “Drew” “Laurel” “Stranger” Goldfrapp “Beethoven’s Silence” Ernesto Cortazar “Tausend Tranen Tief” Blumfeld but Scala & Kolacny Brothers’ version is sadder.
  9. Just popping in but could be Beau’s Lines, caused by zinc deficiency. I’d say it’s a mineral/vitamin problem, too.
  10. I asked a virologist about antibodies and he said not to worry because larger studies are showing that infected people are making them but that in a few, they might not be sticking around very long. That’s not a problem because the memory B cells will proliferate and make the antibodies if a person gets infected with the virus again. There were two larger studies that showed this but one small study that had slightly different results. It’s still being studied. I’ll try to sum up better what he said tomorrow or Friday. Today I am short on time because I have to work. 🙂
  11. One of China’s vaccines is moving on to Phase 3 clinical trials. This is the first inactivated virus vaccine to show efficacy. https://www.reuters.com/article/us-health-coronavirus-china-vaccine/china-to-run-human-coronavirus-vaccine-trial-in-uae-idUSKBN23U2H8
  12. Antibodies are not the last word when it comes to immunity. Cell-mediated immunity is also important and that is not measured by antibodies. Long-term immunity is conferred through memory cells. Your body might "dismantle" antibodies but keep the instructions for making those antibodies in the memory cells. The scientists who are on other boards I'm following, including virologists and other researchers, are all saying that asymptomatic cases are making antibodies but that they don't stick around. However, it is not necessary for them to stick around because the memory cells have the instructions and your body can use those instructions if it sees the virus again at some point in the future. Some diseases do result in long-term, detectable antibodies, but not all do. It just depends on the pathogen and the immune system. (Also, it's not easy to test for the presence of these memory B cells so, unless someone develops an accurate test that can detect the memory B cells, we won't be testing. This is why antibodies are not going to give us complete information as to who has been infected.) If anyone who knows more about immunology wants to correct any of this, please do.
  13. Italians are extremely close to people -- friends, family and even strangers. A greeting and good-bye to someone you know well is a kiss on each cheek and a big hug. In the morning when they get a 1 Euro cup of coffee, they go to the local place and stand shoulder-to-shoulder with others doing the same. It's almost always crowded. Buses and trains are also crowded. They are just much, much physically closer than we are in the US. My husband's family is from northern Italy but it's like this all over.
  14. I don’t think this is going to be a problem with the vaccine. Here’s my very limited understanding of antibodies and immunity. I might not be getting this quite right, though. The asymptomatic cases are probably clearing the virus enough with their innate immune response. They’re able to fight off the virus before it can really take hold. (Antibodies are not the only way we clear infections.) However, that could mean antibody tests might not detect people who have had Covid (because they did not need to make the antibodies or did not make many). Antibodies also shouldn’t stick around too long anyway because that could cause autoimmune problems. Instead memory cells will make a record of antibodies (and possibly the virus? Not sure.) Then, if the virus reappears later, the memory cells will assist in creating what is needed.
  15. From what I read on a board for health care workers, the ground glass opacity is not always affecting the bronchiole tubes. The virus is going into a particular layer of the lung — I forget what it’s called. I should have saved the post. If I come across it again, I’ll post it here.
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