DD14 Asperger's, OCD & ADHD. We work on social skills and take frequent breaks but other than that she has been able to do the coursework for her grade level without too much difficulty. She does have trouble with math. We've been working on Algebra 1 for 2 years now. Everything else she's going through at a good pace.
DS 10 is profoundly Autistic and non-verbal. I do a lot of therapy with him (PT, OT & ST). For school we work mainly on vocabulary, puzzles, play doh, stories, Leap Frog DVD's, computer games, music etc.