I grew up in a town of 5,000 in south-central Nebraska. Western Nebraska is pretty remote. You won't be close to any large cities. The wind can be really strong. And you can get a lot of snow with frigid temperatures in the winter.
On the plus side, the people are generally very nice. If you like the great outdoors, you'll probably find interesting things to do/visit. It will be pretty common place to see people in cowboy boots and hats. Depending on how far west you are, there may be more ranches with cattle, etc, than crop farming.