I have a ton of obesity in my family, so I feel predisposed to it. I've always been able to gain both fat and muscle easily. Losing has been a different matter altogether.
My weight was normal as a child. In 9th grade, I started lifting weights, as part of cheerleading, and cried when I broke 130 pounds (I am 5'4"). I didn't understand that I was gaining muscle.
At the end of 11th grade, I stopped playing sports and immediately ballooned to 165 lbs. I ran with an Army recruiter to drop weight, and squeaked into the Army at 150 lbs. I couldn't pass the weight requirement (which was 125ish), but could pass the body fat requirements (again, because I carry a lot of muscle).
6 years of Army Special Operations, and, even during my most intense training regimen, I never dropped below 145 lbs. I ate low fat/high-carb, which was de rigueur at the time, and was a vegetarian.
Once I got out of the Army, and stopped training like a maniac, my weight just took off. Before I could even blink, I was over 200. Suddenly, I found myself at 225-230 in my late 20s. I struggled with crippling depression and anxiety. I was hirsute and had cystic acne and irregular periods. I tried every diet and workout. Nothing worked. My mom assumed that I was eating bon bons, and gave me a ton of crap about my weight. I came to stay with her for awhile, after my divorce, and, once she saw how much I was training and what I was eating, she finally conceded that something must be wrong with my body. She sent me to an endo.
The endo dx me with PCOS, and told me that my insulin resistance was so bad that I was a "lean, mean, fat-storing machine." I went on Metformin to correct the insulin resistance, and began to lose a modest amount of weight. The acne began to get better. The length of my cycles became more regular. I took antidepressants for my moods. I competed in triathlons, but was still over 200 pounds and unable to lose more weight.
In my mid-30s, I was diagnosed with bipolar disorder and ADHD (inattentive type). In addition to the anti-depressants, I was put on Dexedrine (speed) and a mood stabilizer known for weight loss (Topamax). I suddenly knew what thin people felt like. It was so freeing. I actually had to remind myself to eat. I still trained at the gym like a mad dog, but finally, the weight came off. I dropped to 145-150 -- pretty much the same weight I had been in the Army. I was a size 6. My mood and skin were great, my cycles were regular.
Then, I got pregnant. I had to go off all my meds. I gained 85 lbs during the pregnancy. Boom. Right back to 230+ lbs again. Just like that. Depression was horrible. The worst. I was completely nonfunctional. It got so bad that I finally had to stop nursing and go back on my meds. Things got better. Slowly. The pregnancy weight started to come off. Slowly. I fluctuated between 175-190, depending on the cocktail of meds I was taking.
Then, I got pregnant again. Back to 230 and developed pre-diabetes at 40. Stayed that way for a year until I finally went to a new endo, and begged him to put me on Victoza to try to correct the insulin resistance that had again gotten out of control. My psychiatrist also ran genetic testing. I am compound heterozygous for MTHFR, which is the worst variant. In the 7 months that I have been on Victoza (and the supplements for MTHFR), I have lost 15 lbs. I am 210 pounds, and eat a mostly plant-based diet. My moods are great. My skin is great. I ovulate regularly. The pre-diabetes is gone.
For me, it is clear that this is not just about CICO. There are serious and complicated hormonal/genetic issues at play. One of the things that I have learned is the role glutathione plays in the pathophysiology of obesity, bipolar disorder, and MTHFR. For me, these are all connected, and it has become obvious that there is some breakdown in my glutathione levels. Victoza increases glutathione, so, not surprisingly, it has helped treat both my mood and the obesity/IR. Both my psychiatrist and my endo admit that we are in the infant stages of treating these conditions.