My husband and I have a Shaklee business that we run together. He has another full time job and I home school our ds, so it is part time. It is something that you can work as much as you want and when you want.
http://www.ewing-enterprises.myshaklee.com
We both love their products, use them exclusively in our home and share them with others. It is very rewarding.
I have another home school friend who started her own business called "momma goes green". She orders and sells organic and all natural products -water bottles, baby items, dish cloths, jewelry, etc. It does well.
Another family in our area has a small farm. They supplement their income selling homemade breads, plants and eggs at our local farmers market. They do very well.
Good luck!