The thinking is that Covid is causing NAD+ depletion. NAD stands for nicotinamide adenine dinucleotide. NAD+ is a form of NAD. Here’s an explanation of what it is and what it does: https://www.jillcarnahan.com/2020/11/11/what-is-nad-and-why-is-it-important/ This article discusses NAD+ depletion in more depth and what you can do to build it back up. https://nkalex.medium.com/the-team-of-front-line-doctors-and-biohackers-who-seem-to-have-solved-long-covid-5f9852f1101d Simply, their theory is that COVID19 causes NAD+ depletion. Some people with vitamin deficiencies, existing NAD+ depletion or genetic deficiets in energy metabolism have long term NAD+ dysfunction. The body tries to make up for low NAD+ by feeding in tryptophan, which is the precursor for serotonin, causing low serotonin. Mast cells are activated locally to release serotonin instead, leading to histamine release and mast cell activation issues. Neurological effects are due to low serotonin and NAD+, which also effects the microbiome and general homoeostasis. Energy disruptions are specific to high metabolically active tissues such as the heart and brain. This is further complexed with disruption of the gut-immune axis, mobilization of bacteria, secondary infections - both bacterial and reactivation of dormant neurotrophic viruses. Reactivation of dormant Epstein-Bar virus can open the door to bacterial infections and it is known to trigger the creation of complex and unrelated auto-antibodies, leading to downstream issues. The group treating this mechanism utilizes: Nicotinic acid (most important and not nicotinamide or other forms) Vitamin C Vitamin D Zinc Selenium Quercetin Are you taking any of the above supplements? The nicotinic acid corrects the NAD+ deficiency, so you might want to give that a try (50 mg of nicotinic acid) as well as the others if you’re not taking them.

Probably, even taking into account anti-vaxxers and those who want to wait. More accurate quick testing will help. The anti-virals will help, too. Some are looking pretty dam* good.

Developing and testing psilocybin for depression is in the works. https://www.fiercebiotech.com/biotech/compass-raises-80m-to-take-magic-mushroom-drug-toward-phase-3 https://www.fiercepharma.com/drug-delivery/intelgenx-inks-double-deals-to-develop-oral-film-psychedelics

We have this one made by IQ Air. It’s very quiet and can filter out very small particles. Filters also don't need to be changed often. https://www.amazon.com/IQAir-HealthPro-Medical-Grade-HyperHEPA-Allergies/dp/B087JYMK7Q/ref=sr_1_1_sspa?dchild=1&keywords=iqair&qid=1605381940&sr=8-1-spons&psc=1&spLa=ZW5jcnlwdGVkUXVhbGlmaWVyPUEyMzdSWVBBMElSQlFJJmVuY3J5cHRlZElkPUEwMzIwNDI5M01OVzhRWlhBM0FHNCZlbmNyeXB0ZWRBZElkPUEwMDg0OTI2MVpZWERLN05JTFBSRSZ3aWRnZXROYW1lPXNwX2F0ZiZhY3Rpb249Y2xpY2tSZWRpcmVjdCZkb05vdExvZ0NsaWNrPXRydWU= They also make a smaller unit.

We have it, too. So much nicer to bypass the long lines and not have to remove shoes.

Pfizer's vaccine is more than 90% effective. Operation Warp Speed was hoping for at least 50%. No serious safety concerns reported. Most health problems occur within two months of vaccines hence the two month wait. They will continue monitoring both efficacy and safety. Pfizer enrolled 43,538 people. 38,955 have received their second vaccination. 46% diverse backgrounds. Pfizer has set up 150 clinical trials to test their vaccine in six countries, including the US, which is testing it in 39 states. Initially, they were going to end the interim analysis when 32 events (Covid cases) occurred. They ended up having 94 events so almost three times as much data to analyze. Pfizer is planning to submit their Emergency Use Authorization (EUA) to the FDA next week, the third week of November. the Data and Safety Monitoring Board analyzes data as well. They are secret in order to prevent vaccine developers from lobbying. https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-announce-vaccine-candidate-against https://www.pfizer.com/news/hot-topics/albert_bourla_discusses_covid_19_vaccine_efficacy_results

You would need a device made by a trustworthy company if you were to try it. You would also need to know what wavelength is suggested. Many of the devices on the market are too weak and/or do not deliver the correct wavelength. Some of the FDA approved devices are not worth buying because the FDA has been known to approve devices that won’t harm but also won’t help. If you buy a device, use what is used in research. It’s not likely you’d see immediate improvement. I am trialing a device on my ears to see if it will help improve my hearing and plan to use it for as long as six months. Michael Hamblin at Harvard has done a lot of research in photobiomodulation. It affects mitochondria. Your daughter’s problem is not her mitochondria but her anatomy. In that case balloon sinuplasty might be a better choice. Ask her ENT and if you do go that route, find someone who has done a lot of them.

Dp

I use a Joovv red and near infrared light device on my skin and own a laser light as well. I do not use either for sinus but do use them to improve hearing and retinas. What device are you thinking of using? Vielight? Balloon sinuplasty might be another option.

An article about the mink variant: https://www.statnews.com/2020/11/05/spread-of-mutated-coronavirus-in-danish-mink-hits-all-the-scary-buttons-but-fears-may-be-overblown/ Francois Balloux’s response to the media coverage: https://mobile.twitter.com/BallouxFrancois/status/1324085761449304067 Denmark has been wanting to close all mink farms for awhile now, well before Covid. The date that was set to do this was either 2021 or 2024. I don't recall. This was a good reason to do so. I imagine TWiV will discuss the variant soon.

Yes, that's a good idea. They are using minks in some studies already. This would be a good opportunity as well, I would think.

Human recombinant soluble ACE2 has been found to work in a severe case of Covid. Granted, they will have to try this on more patients but it looks promising. https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30418-5/fulltext An article from April that explains in layman's terms how hrsACE2 works: https://www.sciencedaily.com/releases/2020/04/200402144526.htm The Covid virus needs to bind to a specific protein on the host's cell in order to enter the cell and replicate. That protein is called ACE2 and it acts as the "door" that the virus uses to get into the cell. Scientists developed a therapy using other "doors" not connected to a cell that the Covid virus will attach to. Because those doors are not attached to a cell, the virus is not able to replicate and spread as easily. Pretty cool.

Oh my. Hoping surgery went well for Ri. As if this year hasn't been hard enough.

Derek Lowe discusses the variant found in minks. Posters in the comment section address many of the concerns. https://blogs.sciencemag.org/pipeline/archives/2020/11/05/dont-make-mine-mink Denmark is culling and closing down to reduce spread and the possibility of a second wave. They don't want more cases. From what I've read elsewhere, the vaccines will be effective against this variant. Iirc, Denmark will use AstraZeneca. Maybe some others as well.

Your symptoms do sound suspiciously like Covid. If you're interested, some of the blood centers will test for Covid antibodies for free. It’s likely you would still have them. Glad you all came out of whatever you had okay. I've definitely been exposed but haven't had any symptoms.

He sure is handsome. Glad he's eating again and I hope he'll be bouncing back soon.

We had three dogs and numerous indoor/outdoor cats when I was a kid. Everyone got along just fine, even newborn kittens. In fact, our Siberian Husky would move the kittens back to their cozy box upstairs if they happened to stumble down the stairs. He would put them in his mouth. Mama cat was fine with it. Amazingly.

I'm not sure what they're prescribing but if anyone has gout, they might be in a good position if the dosage is similar! My husband's cousin in Lombardy, for instance, has gout and takes Colchicine. LOL Now if we can just get an accurate, rapid, cheap diagnostic test...

I posted it on the big thread, too. 🙂

No problem. I'll delete it. :)

Results from the larger ColCorona Study will come out in December. That should be interesting. Colchicine looks like a game changer but we’ll have to wait and see those results. Here’s more if you’re interested: https://www.colcorona.net/

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The gout medication Colchicine is working very well in moderate to severe Covid patients. If you or a loved one gets even moderately sick, you should ask for it. Print out the study and show it to them. https://www.hindawi.com/journals/cjidmm/2020/8865954/ Results: An initial analysis performed on all patients, irrespective of the availability of two timepoint inflammatory markers, revealed a lower mortality (49.1% versus 72.9%, ), a lower percentage of intubations (52.8% versus 73.6%, ), and a higher discharge rate (50.9% versus 27.1%, ), in the patients who received colchicine. Patients in the final comprehensive analysis groups (34 in the colchicine group and 78 in the control group) had a similar prevalence of comorbid medical conditions, except for renal failure, which was higher in the control group (65.3% versus 35.2%, ). HTN (71.8% versus 52.9%, ) and DM (51.3% versus 32.4%, ) were also more prevalent in the control group, although the difference was not statistically significant. Patients who received colchicine had a lower mortality than the control group (47.1% versus 80.8%, ), lower rate of intubations (47.1% versus 87.2%, ), and a higher discharge rate (52.9% versus 19.2%, ). Patients in the colchicine group also showed a more significant decrease in inflammatory markers for D-dimer (), CRP (), and ferritin (). Conclusions. Our study demonstrates that colchicine improved outcomes in patients with COVID-19 receiving standard of care therapy. Future randomized, placebo-controlled clinical trials to assess the potential benefit of colchicine in COVID-19 are warranted.

This study supposedly has some serious flaws. It was discussed on a forum where I lurk. Regardless, it’d be good to know more about the reinfections.

I have this book on my reading list. It discusses our individual microbiota and how that affects our mental state. The brain, central nervous system and gut microbes communicate with one another which influences how we feel. The Psychobiotic Revolution: Mood, Food and the New Science of the Gut-Brain Connection (link to Amazon) Additionally, low daily protein intake can cause low-grade inflammation. Because your son is a young teen who also works out, he needs a bit more protein. No need to go overboard but it might be worthwhile to track his protein intake for a few days. Magnesium is also sorely lacking in most people’s diets and deficiency can cause anxiety (and many other problems). That’s worth tracking, too, or you could just look up foods high in magnesium to see if he’s eating enough. If not, he could take a good quality, daily supplement.