Yes, I have. Most nights, I'm home alone during bedtime and many nights, all night with the six kids. Enter a stomach bug. I had 4 kids who aren't feeling well and throwing up and 2 very active night owls who were extremely cranky b/c they needed to go to sleep.
Drug them because it is easier? Absolutely. I gave my 1 & 3 year olds melatonin to go to bed (not early but on time) so I could take care of my other 4 who were throwing up.