It depends. Most do I think. I'm left handed and I certainly do.
People are left handed for various reasons. Some people right brained. Some people's brains are actually mirror images of normal. If the side of his brain that is dominant is the opposite of most people's then, yeah, he probably will learn differently.
Just watch your son and learn what is best for him. There are some really awesome websites if you google. Don't have any expectations either way. Just do what works. Oh, and don't get frustrated. My mom always did. In the end, I am far more efficient doing things my way than being forced to act like a right hander.