ktgrok Posted May 9, 2016 Share Posted May 9, 2016 So, they've found two genes that seem to influence twinning (there are surely more). If you have done 23 and Me you can go to "tools" and search your raw data for them, they don't seem to be in promethease or livewello yet. The first gene is more linked, rs11031006, with an 18% increase in your chance of twins for each "G" copy you have. (normal is A). I have both G copies...my Dad is a fraternal twin, he has another set of fraternal twin brothers, and his mom, my maternal grandmother, was a twin herself. Seems I inherited the hyper ovulation gene. (no one tell my husband!). The other gene is rs17293443 and there is a 9% increase for a C allele (I don't have those). An article: http://www.npr.org/sections/health-shots/2016/04/28/475905344/genetic-variations-help-make-fraternal-twins-more-likely?sc=17&f=1001&utm_source=iosnewsapp&utm_medium=Email&utm_campaign=app 7 Quote Link to comment Share on other sites More sharing options...
maize Posted May 9, 2016 Share Posted May 9, 2016 Ah neat! I'll have to go check my 23andMe data. I don't know of any twins in the family, so we're probably negative for that gene. Quote Link to comment Share on other sites More sharing options...
wapiti Posted May 9, 2016 Share Posted May 9, 2016 Interesting! I only have 23andme results for one of my kids, and he is GG for rs11031006. My dad was a fraternal twin. 1 Quote Link to comment Share on other sites More sharing options...
maize Posted May 9, 2016 Share Posted May 9, 2016 I'm AG on the first and TT on the second. Quote Link to comment Share on other sites More sharing options...
maize Posted May 9, 2016 Share Posted May 9, 2016 Ooh, dh is GG for the first gene, maybe I'll get some twin grandkids ;) off to check the kids (two have been genotyped...) Quote Link to comment Share on other sites More sharing options...
maize Posted May 9, 2016 Share Posted May 9, 2016 No twins in dh's family that I know of, but the women do tend to be very fertile. Wonder if this impacts overall fertility? Quote Link to comment Share on other sites More sharing options...
maize Posted May 9, 2016 Share Posted May 9, 2016 Both my dd's are GG. Quote Link to comment Share on other sites More sharing options...
Farrar Posted May 9, 2016 Share Posted May 9, 2016 Ooh. I have twins. And they're all up and down my family. This actually makes me want to do 23 and me more... 2 Quote Link to comment Share on other sites More sharing options...
Katy Posted May 9, 2016 Share Posted May 9, 2016 One G and one C!!! I keep dreaming about having twins. How cool! 1 Quote Link to comment Share on other sites More sharing options...
SNPedia Posted May 10, 2016 Share Posted May 10, 2016 Both SNPs, rs11031006 and rs17293443, are already in SNPedia, which means they will be in upcoming Promethease reports. 1 Quote Link to comment Share on other sites More sharing options...
ondreeuh Posted May 10, 2016 Share Posted May 10, 2016 So, they've found two genes that seem to influence twinning (there are surely more). If you have done 23 and Me you can go to "tools" and search your raw data for them, they don't seem to be in promethease or livewello yet. The first gene is more linked, rs11031006, with an 18% increase in your chance of twins for each "G" copy you have. (normal is A). I have both G copies...my Dad is a fraternal twin, he has another set of fraternal twin brothers, and his mom, my maternal grandmother, was a twin herself. Seems I inherited the hyper ovulation gene. (no one tell my husband!). The other gene is rs17293443 and there is a 9% increase for a C allele (I don't have those). An article: http://www.npr.org/sections/health-shots/2016/04/28/475905344/genetic-variations-help-make-fraternal-twins-more-likely?sc=17&f=1001&utm_source=iosnewsapp&utm_medium=Email&utm_campaign=app I am G/G for the first SNP - no twins in my family unless I go back several generations. Interesting. Quote Link to comment Share on other sites More sharing options...
The Girls' Mom Posted May 11, 2016 Share Posted May 11, 2016 I was excited to hear that! I'm still waiting on the marker for identicals, because I'm convinced there is one. Both of my grandmothers had a set of identical twin sisters, and I have a set of identical twin girls. My oldest also had a twin that never developed past 6 weeks or so. I think there is something genetic about the likelihood of an egg splitting. 1 Quote Link to comment Share on other sites More sharing options...
Ravin Posted May 11, 2016 Share Posted May 11, 2016 I was excited to hear that! I'm still waiting on the marker for identicals, because I'm convinced there is one. Both of my grandmothers had a set of identical twin sisters, and I have a set of identical twin girls. My oldest also had a twin that never developed past 6 weeks or so. I think there is something genetic about the likelihood of an egg splitting. I suspect the same in my family. At a family reunion on my dad's side, I did the math and determined that the family had a 1 in 30 birthrate for identical twins, as opposed to the general population rate of about 1 in 100 births. 1 Quote Link to comment Share on other sites More sharing options...
ktgrok Posted May 11, 2016 Author Share Posted May 11, 2016 Agreed, they may be something there. Interestingly, my father is supposedly an identical twin. And he does look a lot like his twin. But, all the boys in the family look a lot a like. And it seems beyond belief that my grandma was a twin herself, (unknown if identical or fraternal, and twin died at birth), then had a set of identical twins AND a set of fraternal twins. (the other set is very obviously fraternal...one blonde one dark like the other brothers). Seems way more likely me that both sets are fraternal,a and my dad and his twin just happen to look alike. I mean, it isn't like they were doing DNA testing back then, you know? I keep this theory to myself, as Dad likes being an identical twin :) Quote Link to comment Share on other sites More sharing options...
Ravin Posted May 11, 2016 Share Posted May 11, 2016 ktgrok, do you have a first cousin who is the child of your father's twin? Comparing genetic data with such a first cousin could be enlightening on that subject for your own curiosity without bursing your father's bubble. 1 Quote Link to comment Share on other sites More sharing options...
ktgrok Posted May 11, 2016 Author Share Posted May 11, 2016 ktgrok, do you have a first cousin who is the child of your father's twin? Comparing genetic data with such a first cousin could be enlightening on that subject for your own curiosity without bursing your father's bubble. No, he never had children. Probably for the best, his wife was pretty mentally unstable. Either way, I think Grandma should have had her own reality show. She gave birth to 5 boys in 3 years! A set of twin boys, a year later a singleton boy, and a year later another set of twin boys. Several years later she finally had a girl, who to her great distress ended up being a total tomboy :) 1 Quote Link to comment Share on other sites More sharing options...
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