We went from ME to AR with 10 kids, 2 cats and a dog(yellow lab) and I lived to talk about it. Sort of. :D
We did stay in a hotel 2 nights and didn't have any trouble. I think it was at Super 8s? On the road we would stop and the kids would walk all the animals, yes, even the cats LOL. Of course the cats had performance anxiety, but we managed.