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A review of executive function deficits in autism spectrum disorder and attention-deficit/hyperactivity disorder (NCBI)


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I thought the findings in this study might be interesting,  particularly to those of us with kids that have both the ASD and ADHD labels (the part I put in bold was of most interest to me) and thought I would share.

A review of executive function deficits in autism spectrum disorder and attention-deficit/hyperactivity disorder
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869784/
 

"Conclusion
This article reviewed 26 studies that examined EF comparing ASD and ADHD children. In light of the findings set out in this review, the ASD + ADHD group appears to share impairments in flexibility and planning with the ASD group, while it shares the response inhibition deficit with the ADHD group (Figure 1). Conversely, deficit in attention, WM, preparatory processes, fluency, and concept formation does not appear to be distinctive in discriminating from ASD, ADHD, or ASD + ADHD group. These findings are in line with the new criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, where the diagnoses of ASD and ADHD are no longer mutually exclusive. In fact, on the basis of neurocognitive endophenotype, the common co-occurrence of EF deficits seems to reflect an additive comorbidity, rather than a separate condition with distinct impairments. The identification of neurocognitive endophenotype in children with ASD, ADHD or ASD + ADHD could play an important role for the treatment implication because EF cognitive training may change the underlying neural mechanisms to improve the real-world function or clinical symptoms. Nonetheless, the definition of the combined phenotype (ASD + ADHD) needs to integrate genetic, neuroimaging, neurocognitive, and clinical evidences."

 

 

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Something interesting about that study?  Is the study that they cite, which identified 'polymorphisms of 25 kDa', which is also the 'Heat Shock Protein 25, HSP25. Where their are 2 variants of it, (polymorphisms).

 

This relates to the thread that I started, on 'Autism. ASD and Fever'.  Where HSP25  is a factor.

 

 

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I haven't had the chance to go down the list of references but I have it in my pending file along with a host of other research I'm going through. Thank you for pointing that out! Yes, I remember your thread. I'll be looking into it.

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