Danestress Posted May 25, 2017 Share Posted May 25, 2017 Take these as facts: Across the general population, 12% of people will develop a certain disease by age 65. There are six genotypes that indicate risk (but not certainty - none is a guarantee of developing or not developing that disease). A person with the "highest risk" genotype had a 12 times greater risk of developing that disease by 65 than average. 2% of people in the population have this high risk genotype. Assume there are no other factors that are relevant (no other risk factors, no protective lifestyles or treatment). How would you calculate the risk of a person who has the riskiest genotype? What other information would you need to know? The thing I am hung up on is that we aren't comparing people with the riskiest genotype to a person with a different genotype, but with the average risk of all people, which includes other people with that genotype. Anyone? Quote Link to comment Share on other sites More sharing options...
sgo95 Posted May 25, 2017 Share Posted May 25, 2017 Not an expert here...but I do have a few questions: What percentage of the population is in each genotype? Is there overlap? What is the risk of of each genotype? Currenlty we only know that the highest risk group is 12 times riskier than the lowest risk genotype. I think if you had these answers, then you could calculate every group's risk. Quote Link to comment Share on other sites More sharing options...
sgo95 Posted May 25, 2017 Share Posted May 25, 2017 Actually, I think I'm wrong. Maybe you just need the highest group's actual risk number, not relative to the lowest risk group. Quote Link to comment Share on other sites More sharing options...
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