Popular Post lauraw4321 Posted March 11, 2020 Popular Post Posted March 11, 2020 (edited) Just thought I would share that I will be going to my first appointment to participate in the NIH clinical trial of the potential CV-19 vaccine. It's an mRNA vaccine, meaning not an attenuated or live virus. The idea is that my body will code a protein that triggers an antibody response that's effective against the virus. I'll receive two doses of the vaccine, have several blood draws, and be monitored over several months. I have several friends who work in genetic research and they've done some side research for me. The worst adverse reactions in previous mRNA studies were site reactions and anaphylaxis. I have never had an adverse vaccine reaction, so I think even the risk of that to me is pretty low. I've always been a really big fan of John and Abigail Adams, and I feel like I'm doing a (much lower risk) version of what she bravely did - inoculate herself and her children against smallpox. I'll keep you updated! ETA - Question was asked on previous thread. I'm in the US (Seattle). This study is funded by the NIH. Edited March 11, 2020 by lauraw4321 22 30 Quote
JennyD Posted March 11, 2020 Posted March 11, 2020 You're awesome, Laura. Thanks for doing this, and please do keep us posted. 3 Quote
PrincessMommy Posted March 11, 2020 Posted March 11, 2020 (edited) 2 minutes ago, lauraw4321 said: Just thought I would share that I will be going to my first appointment to participate in the NIH clinical trial of the potential CV-19 vaccine. It's an mRNA vaccine, meaning not an attenuated or live virus. The idea is that my body will code a protein that triggers an antibody response that's effective against the virus. I'll receive two doses of the vaccine, have several blood draws, and be monitored over several months. I have several friends who work in genetic research and they've done some side research for me. The worst adverse reactions in previous mRNA studies were site reactions and anaphylaxis. I have never had an adverse vaccine reaction, so I think even the risk of that to me is pretty low. I've always been a really big fan of John and Abigail Adams, and I feel like I'm doing a (much lower risk) version of what she bravely did - inoculate herself and her children against smallpox. I'll keep you updated! Sounds very interesting. How did you get involved with the study? I'd love to look into it too (being 20min from NIH) Edited March 11, 2020 by PrincessMommy 2 Quote
catz Posted March 11, 2020 Posted March 11, 2020 Wow - that is exciting and fascinating. Thank you for being a pioneer for all of us. I hope it works it works exactly as intended. ❤️ 3 Quote
lauraw4321 Posted March 11, 2020 Author Posted March 11, 2020 1 minute ago, PrincessMommy said: Sounds very interesting. How did you get involved with the study? I'd love to look into it too (being 20min from NIH) They announced the study locally (Seattle) and I went to clinicaltrial.gov and found the contact information. I emailed them, and then had a phone screening of about 25 minutes. Although I'm a lawyer, I previously worked in-house at a biotechnology company, so I probably know a bit more than average about clinical trials and how they work. There was a lot of press about the study, so I figured that they probably wouldn't need me, but they followed up really quickly. I forwarded the consent document to several folks I know who are either doctors, genetic researchers or genetic counselors to get their take. I will probably be part of the first group, which means I get the smaller dose, which means lower risk. The research of the previous similar vaccines indicates that this kind of vaccine is probably not as effective as more traditional vaccines, but they can be made so much more quickly than traditional vaccines. 11 Quote
sassenach Posted March 11, 2020 Posted March 11, 2020 Thank you! It's encouraging that phase 1 studies are launching. Crossing my fingers that it all goes smoothly! 2 Quote
medawyn Posted March 11, 2020 Posted March 11, 2020 Awesome! I know someone working on that vaccine. 2 Quote
mommyoffive Posted March 12, 2020 Posted March 12, 2020 You are so awesome. Thank you. Keep us posted when you can. Quote
lauraw4321 Posted March 12, 2020 Author Posted March 12, 2020 Our school system announced they are closing Friday and may stay closed for 5-6 weeks. Meanwhile, the vaccine clinic called and asked some questions. One was whether I as eaten poppy seeds recently. I did yesterday. That may disqualify me. It’s a weird world. Quote
Pen Posted March 12, 2020 Posted March 12, 2020 57 minutes ago, lauraw4321 said: Our school system announced they are closing Friday and may stay closed for 5-6 weeks. Meanwhile, the vaccine clinic called and asked some questions. One was whether I as eaten poppy seeds recently. I did yesterday. That may disqualify me. It’s a weird world. Oops. That might have shown up if they took samples as too similar to an opiate. I hope it being only poppy seeds will allow you to participate. If you get to participate, Are you getting an amount that’s looking for safety or effectiveness or both? Quote
lauraw4321 Posted March 12, 2020 Author Posted March 12, 2020 5 hours ago, Pen said: If you get to participate, Are you getting an amount that’s looking for safety or effectiveness or both? Both, I think. There are three groups of 15 people. Each group are given a slightly higher dose than the others. They are monitoring us for negative reactions and also measuring our blood for 14 months for antibodies. They are also doing “secondary research” where they put our blood in long term storage and can study it in ways they haven’t yet decided. 1 Quote
Ausmumof3 Posted March 12, 2020 Posted March 12, 2020 When they are testing vaccine like that do some people end up getting a placebo vaccine type thingy? Or is that not necessary. Realising how little I know about this. Quote
lauraw4321 Posted March 12, 2020 Author Posted March 12, 2020 25 minutes ago, Ausmumof3 said: When they are testing vaccine like that do some people end up getting a placebo vaccine type thingy? Or is that not necessary. Realising how little I know about this. Unless the consent form is not accurate, which I doubt, everyone gets the vaccine and there are no placebos. I think because the effectiveness of the vaccine isn’t really subjective there’s no need for a placebo, but I could be entirely wrong. 1 Quote
Xahm Posted March 12, 2020 Posted March 12, 2020 3 hours ago, lauraw4321 said: Unless the consent form is not accurate, which I doubt, everyone gets the vaccine and there are no placebos. I think because the effectiveness of the vaccine isn’t really subjective there’s no need for a placebo, but I could be entirely wrong. Cool that you're doing this. My kids and I have been a part of several vaccine studies over the years. Eventually, I bet, there will be a placebo added to the study so that they can sort out real vs imagined side effects, but I guess they aren't there yet with this study. 1 Quote
lauraw4321 Posted March 12, 2020 Author Posted March 12, 2020 6 minutes ago, xahm said: Cool that you're doing this. My kids and I have been a part of several vaccine studies over the years. Eventually, I bet, there will be a placebo added to the study so that they can sort out real vs imagined side effects, but I guess they aren't there yet with this study. Interesting, yes. They seem to be focused on really measurable things. Like I have to take my temperature regularly. 3 Quote
mommyoffive Posted March 12, 2020 Posted March 12, 2020 So you are doing it? The poppy seeds didn't disqualify you? Quote
Negin Posted March 14, 2020 Posted March 14, 2020 On 3/11/2020 at 5:02 PM, lauraw4321 said: Just thought I would share that I will be going to my first appointment to participate in the NIH clinical trial of the potential CV-19 vaccine. It's an mRNA vaccine, meaning not an attenuated or live virus. The idea is that my body will code a protein that triggers an antibody response that's effective against the virus. I'll receive two doses of the vaccine, have several blood draws, and be monitored over several months. Laura, thank you so much for doing this. 1 Quote
lauraw4321 Posted March 14, 2020 Author Posted March 14, 2020 On 3/12/2020 at 10:31 AM, mommyoffive said: So you are doing it? The poppy seeds didn't disqualify you? Still not sure - waiting for lab results to come back. I'll let you know! 2 Quote
PrincessMommy Posted March 16, 2020 Posted March 16, 2020 Saw this today and thought of you @lauraw4321 https://www.dailymail.co.uk/news/article-8117913/Coronavirus-vaccine-test-opens-US-volunteer-gets-1st-shot.html I know results won't be known for another 12 months or more, but here's hoping it's all positive. 2 Quote
lauraw4321 Posted March 17, 2020 Author Posted March 17, 2020 Yes, this is the trial, but I won’t get to participate. They called today to let me know. Several of my liver enzymes came back elevated today. I texted my PCP best friend and she thinks it’s likely from my anti-depressant, but I need to eventually follow up with my real doc. You know, when there’s no pandemic going on. 6 Quote
mommyoffive Posted March 17, 2020 Posted March 17, 2020 I am sorry you don't get do the trail. Thank you for volunteering for it. 2 Quote
Recommended Posts
Join the conversation
You can post now and register later. If you have an account, sign in now to post with your account.