For me, it would depend on how big and athletic the girl is, as well as the age group. But, my answer would very likely be no. If this is a league that includes 6th-8th graders, I wouldn't even consider it.
My stepdaughter played tackle football for one year, in 6th grade in a 5/6th grade league. None of the boys had hit their growth spurt (good/big 6th graders could play up in the 7/8th league), while she was about 5'3 and over 100lbs. She was one of the best players, and we really didn't worry about her any more than we did her brothers. However, when we looked at the 7/8th league, we d