As far as what I am doing to address the feeling being out of sync with my daughter (she is only four and it is shattering that she already feels this way):
I am getting books that deal with emotions and socials situations and reading them a loud to her. It helps facilitate conversations.
I am empathizing, listening and continually keeping the discussion open with her about it. I am also discussing with her that a lot of people don't feel in sync with others around them- a lot of people come from different perspectives, home lives, physical differences and so forth but we can still make an effort to reach out and across our differences to others- that they may have to reach through their own muck to get to her as well.
(This may sound like a contradiction to the above) I am helping her understand herself and how her mind works. If she's looking to others, especially outside of the family, to help her understand her intensities- then she is going to feel strange.
She has two friends that are on her level- I am clinging to them, fostering playdates and so forth in hopes that these friendships could be lifelines for a long time.
I am going to gifted conferences and am planning to join a support group this fall for families with giftedness. There are a couple here and I haven't decided which one to join.