My dd13 has mild CP with moderate brain damage. Mostly we just go r.e.a.l. slow, and she works below "grade level". We keep it basic, no frills.
My ds9 has Down syndrome. We use McRuffy K for math. We used 100EZ lessons for reading until he couldn't do it anymore, and we have just recently switched over to CLE's Learn to Read. We practice handwriting every day. We also hired a part-time tutor this semester to give me a break.
I also have 3 "typical" kids...9,3, and almost 2.