I've had 3 due to bleeding two times after menopause. The first time they didn't get enough tissue so it had to be repeated. I've had two natural childbirths. They told me to take 600-800 mg ibuprofen an hour before. Since it didn't seem to help, the 2nd time i took 5 mg Vicodin. That didn't help either. So then the 3rd time I took 7.5 mg oxycontin and still I felt like I'd had nothing! I only felt tired about 2-3 hours after. The pain was from the instrument going through and slightly dilating the cervix but i think also the suctioning to get tissue. She told me this time she was pretty vigorous and did it 3 times because there wasn't much there to be had.